Preparación y Estudio de Materiales Magnéticos Multifuncionales de Carácter Molecular (M4)

El grupo M4 se consolida en torno a un objetivo motriz centrado en la preparación y estudio de materiales magnéticos multifuncionales de carácter molecular. Se trata de un objetivo amplio y abierto a muchas posibilidades. Un campo importante de la actividad investigadora está centrada en lo que se ha dado en llamar Nanociencia Molecular, desarrollando agrupamientos magnéticos mediante química molecular. Estos agrupamientos pueden ser moléculas de alto espín, y entonces se trata de generar arquitecturas de ensamblaje de las mismas y su eventual colocación en superficies. También pueden consistir en partículas magnétics nanoscópicas obtenidas dentro de matrices poliméricas, altamente multifuncionales, de acuerdo con tecnologías propias, patentadas y licenciadas por miembros del grupo. Siendo un objetivo de investigación básicamente fundamental, no excluye las importantes vertientes aplicadas que tiene. Finalmente, el grupo está interesado en la termometría en la nanoescala, donde ha desarrollado un termómetro molecular autoreferenciable cuyas aplicaciones en una variedad de campos están siendo exploradas.

http://www.unizar.es/m4/

Apellidos, Nombre Categoría profesional Extensión Email
Beltrán López, Jesús Francisco CTR-Proy-Lcd jebelt@unizar.es
Burriel Lahoz, Ramón Profesor de Investigación CSIC 841223 burriel@unizar.es
Campo Ruiz, Jesús Javier Investigador Científico CSIC 842742 / 842452 jcampo@unizar.es
Cañadillas Delgado, Laura Doctor Vinculado 6957 (CUD) lauracd@unizar.es
Cases Andreu, Rafael Profesor Titular UZ 843346 cases@unizar.es
Castro Corella, Miguel Profesor Titular UZ 842528 mcastro@unizar.es
Evangelisti Crespo, Marco Investigador Científico CSIC 843342 evange@unizar.es
Falvello Mancuso, Lawrence R. Catedrático UZ 841179 falvello@unizar.es
Laliena Bielsa, Víctor Contratado a proyecto - Doctor 841257 laliena@unizar.es
Lorusso, Giulia Contratado Juan de la Cierva 842419 giulia.lorusso@csic.es
Luzón Marco, Francisco Javier Doctor Vinculado 842462 jluzon@unizar.es
Mayoral Asensio, Isabel Técnico Especialista Grado Medio (CSIC) 843528 imayoral@unizar.es
Millán Escolano, Ángel Científico Titular CSIC 842461 amillan@unizar.es
Palacios Latasa, Elías Profesor Titular UZ 842467 elias@unizar.es
Piñol Lacambra, Rafael CTR-Proy-Doctor 843347 pinol@unizar.es 0000-0001-7625-4806
Piquer Oliet, Cristina Científico Titular CSIC 843793 cpiquer@unizar.es
Puente Orench, Inés Contratada laboral fijo +33 476 20 75 37 puenteorench@ill.fr
Romeo Martínez, Germán Contratado a proyecto - Grado 843782 gromeo@unizar.es
Multifunctional Molecular Materials

Multifunctional Molecular Materials. This line of research focuses on the synthesis of new materials with architectures based on high-spin molecules, the study of chiral molecular magnetic systems, the study of molecular magnetic systems with mixed valence states and the study of organic magnets.

 

NanoBioMed

NanoBioMed, a nanoscale platform for biology and medicine. This line falls within the field of nanotechnology applied to biology and medicine, in particular, the development of a multifunctional nanoscale platform and its application to biological systems.

 

The ultimate goal is to develop tools for diagnosis and and therapies, especially cancer. This activity addresses several issues:

  1. Synthetic (novel synthetic routes developed by the group, some of this technology has been patented and other is in the process of development.
  2. Manufacturing and functionalization of nanoparticles);
  3. Structural (characterization of nanoparticles using different methods: XRD, TEM, AFM, SAXS, SANS, DLS, ...),
  4. Physical properties (magnetic, optical, ...),
  5. Effectiveness as contrast agents in magnetic resonance imaging in hyperthermic treatment, and
  6. Cellular studies in vitro and in vivo (toxicology, immunology, hematology, cellular internalization, acting on cellular organelles, tissue distribution, ...).

In the current state of development it provides a polymeric nanoplatform which in addition to magnetic functionality can also incorporate luminescent components and anchor groups of biomolecules (proteins in general and specific antibodies). It is composed of biocompatible elements (maghemite and biocompatible polymer), with low toxicity, no hematologic problems , has significant magnetothermic response and acts as an effective contrast agent in MRI . This is a multidisciplinary activity carried out in collaboration with other national groups (Faculty of Veterinary Medicine, Clinical Hospital, Univ Salamanca, Polytechnic University of Madrid, Universidad Complutense, Centro de Investigación Príncipe Felipe) and abroad (University of Aveiro , Univ Pavia, INSA Toulouse, IMEG Sweden, McGill University, Montreal, Canada, CIM Cuba, Technical University of Vienna, University of Lisbon).

 

Magnetic Crystallography with Neutrons and Advanced Neutron Instrumentation

Magnetic Crystallography with Neutrons and Advanced Neutron Instrumentation within the CRG´s framework of the ILL.

This line of research supports work being carried out within the other two research lines of the group when characterization by neutron scattering is required. It also involves the development of advanced instrumentation focused on the improvement and development of existing instruments and the design and construction of new ones. Finally, it also includes a component of National Service by members of the group responsible for coordinating the domestic use of the Spanish Collaborative Research Group (CRG) instruments at the ILL and collaboration with local scientists on selected experiments.

 

Thermometry in the nanoscale

This topic is being developed in closed collaboration with the group of Prof. Luis Carlos, from the University of Aveiro. It is based in the recent discovery by the groups of a molecular system that works as a self-referencing thermometer. The system is very versatile and can be attached to particules, surfaces or processed in a paint. The topic aims to explore the possibilities of this system and its practical applications.

Internacionales

Prof. L. Carlos, CICECO and Aveiro University, Portugal.

Dr. Nuno Silva, CICECO and Aveiro University, Portugal.

Prof. Dante Gatteschi,  Prof. Andrea Caneschi,  European Institute of Molecular Magnetism (EIMM), Florence, Italy. 

Prof. U. Schubert,  Technical University of Wien, Austria.

Prof. Masaaki Ohba, Fukuoka University, Fukuoka, Japan.

Prof. Katsuya Inoue, Hiroshima  University, Hiroshima, Japan.

Prof.  Joel Miller,  Utah University, Salt Lake City, Utah, USA.

Profª. Yuko Hosokoshi, Osaka Prefecture University, Osaka, Japan.

Profª Pasquina  Marzola, Verona University, Verona, Italy.

Dr. Alessandro Lascialfari, Pavia University, Pavia, Italy.

Profª Dusica Maysinger,  McGill University, Montreal, Canada. 

Dr. G. Baldi, Centro Recerche Colorobbia, Sovigliana Vinci, Italy.

Prof. Marc Raspaud and Dr. Julian Carrey, INSA-Toulouse, Toulouse, France.

Prof. Juraj Černák, Department of Inorganic Chemistry, Institute of Chemistry, P. J. Šafárik University in Košice, Košice, Slovakia

Dr. Claudio Sangregorio, University of Florence, Florence, Italy.

Dr. Dino Fiorani, CNR-ICMAT, Rome, Italy.

Prof. Masaki Mito, Kyushu Institute of Technology, Kitakyushu, Japan.

Prof. Rogerio Gaspar, University of Lisbon, Lisboa, Portugal.

Prof. Ruth Duncan, Cardiff University, Cardiff, UK.

Prof. Heinrich Hoffman, EPFL, Lausanne, Swiss.

Prof. Silvio Decurtins, Bern University, Bern, Swiss.

Prof. Jeremy Rawson, Windsor University, Windsor, Canada.

Prof. Paul Lahti, University of Massachusetts, Amherst, Mass., USA.

Dr. Carley Paulsen, CNRS, Grenoble, France.

Dr. Eric Ressouche, CEA-Grenoble, Grenoble, France.

Dr. Jean Pascal Sutter, Toulouse University, Toulouse, France.

Dr. Tatiana Makarova, Umea University, Umea, Sweden.

Dr. Steve Hull, The ISIS Facility, Rutherford Appleton Laboratory, Didcot (UK).

 

Nacionales

Prof. Víctor Sorribas, Cátedra de Toxicología de la Univesidad de Zaragoza, España.

Prof. Eugenio Coronado,  Instituto de Ciencia Molecular, Universidad de Valencia, España.

Dra. Pilar Marco, Instituto de Investigaciones Químicas y Ambientales de Barcelona, España.

Prof. Javier Serrano (Escuela Técnica de Ingenieros de Telecomunicaciones), Zaragoza, España.

Prof. Jaume Veciana Miró Instituto de Ciencias de Materiales de Barcelona, Barcelona, España.

Dr. Manuel Fuentes, Centro Nacional del Cancer de Salamanca (CSIC), Salamanca, España.

Dr. Simó Schwartz, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, España.

Prof. Lluisa Pérez-García, IN2UB, Universitat de Barcelona, Barcelona, España.

Dr. Jose Antonio Plaza, Institute of Microelectronics of Barcelona, IMB-CNM (CSIC), Barcelona, España.

Dr. Jordi Llop, BiomaGUNE, San Sebastian, España.

Prof. Juan Novoa, Universidad de Barcelona, España.

Dr. Enrique Navarro, Instituto Pirenaico de Ecología (CSIC), Zaragoza, España.

Dr. Jesús Martínez de la Fuente, Instituto de Nanociencia de Aragón, Zaragoza, España.

Prof. José Mª Valpuesta, Centro Nacional de Biotecnología (CSIC), Madrid, España.

Prof. Marcelo de las Heras, Universidad de Zaragoza, Zaragoza, España.

Dra. Mª Jesús Vicent, Instituto Príncipe Felipe, Valencia, España.

Profª, Mª Puerto Morales, Instituto de Ciencia de Materiales de Madrid (CSIC), Madrid, España.

Prof. Amilcar Labarta, Universidad de Barcelona, Barcelona, España.

Prof. Fernando Rodríguez, Universidad de Cantabria, Santander, España.

Prof. José González Calbet, Universidad Complutense, Madrid, España.

Dr. Miquel Vellvehi, Instituto de Microelectronica of Barcelona, IMB-CNM (CSIC), Barcelona, España.

Prof. Larry Falvello, University of Zaragoza, Zaragoza, España.

Development of magnetic nanoparticles and ferrofluids for biomedical applications

Highly stable PBS suspensions of colloidal magnetic nanoparticles can be prepared for a variety of applications: MRI contrast agents, hiperthermia, magnetic separation and others. The particles, which can simultaneously incorporate a luminescent element, a mulecular thermometer or a drug, can also be vectorised with a large number of antibodies and proteids.

 

Nanoscale thermometry

Developments for mapping temperature with submicrometric resolution are accepted uppon request. They include application in microelectronics, chips thermometry, intracellular thermometry and nanofluids.

El grupo M4 se consolida en torno a un objetivo motriz centrado en la preparación y estudio de materiales magnéticos multifuncionales de carácter molecular. Se trata de un objetivo amplio y abierto a muchas posibilidades. Un campo importante de la actividad investigadora está centrada en lo que se ha dado en llamar Nanociencia Molecular, desarrollando agrupamientos magnéticos mediante química molecular. Estos agrupamientos pueden ser moléculas de alto espín, y entonces se trata de generar arquitecturas de ensamblaje de las mismas y su eventual colocación en superficies. También pueden consistir en partículas magnétics nanoscópicas obtenidas dentro de matrices poliméricas, altamente multifuncionales, de acuerdo con tecnologías propias, patentadas y licenciadas por miembros del grupo. Siendo un objetivo de investigación básicamente fundamental, no excluye las importantes vertientes aplicadas que tiene. Finalmente, el grupo está interesado en la termometría en la nanoescala, donde ha desarrollado un termómetro molecular autoreferenciable cuyas aplicaciones en una variedad de campos están siendo exploradas.

http://www.unizar.es/m4/

CTR-Proy-Lcd
jebelt@unizar.es
Profesor de Investigación CSIC
841223
burriel@unizar.es
Investigador Científico CSIC
842742 / 842452
jcampo@unizar.es
Doctor Vinculado
6957 (CUD)
lauracd@unizar.es
Profesor Titular UZ
843346
cases@unizar.es
Profesor Titular UZ
842528
mcastro@unizar.es
Investigador Científico CSIC
843342
evange@unizar.es
Catedrático UZ
841179
falvello@unizar.es
Contratado a proyecto - Doctor
841257
laliena@unizar.es
Contratado Juan de la Cierva
842419
giulia.lorusso@csic.es
Doctor Vinculado
842462
jluzon@unizar.es
Técnico Especialista Grado Medio (CSIC)
843528
imayoral@unizar.es
Científico Titular CSIC
842461
amillan@unizar.es
Profesor Titular UZ
842467
elias@unizar.es
CTR-Proy-Doctor
843347
pinol@unizar.es
Científico Titular CSIC
843793
cpiquer@unizar.es
Contratada laboral fijo
+33 476 20 75 37
puenteorench@ill.fr
Contratado a proyecto - Grado
843782
gromeo@unizar.es
Multifunctional Molecular Materials

Multifunctional Molecular Materials. This line of research focuses on the synthesis of new materials with architectures based on high-spin molecules, the study of chiral molecular magnetic systems, the study of molecular magnetic systems with mixed valence states and the study of organic magnets.

 

NanoBioMed

NanoBioMed, a nanoscale platform for biology and medicine. This line falls within the field of nanotechnology applied to biology and medicine, in particular, the development of a multifunctional nanoscale platform and its application to biological systems.

 

The ultimate goal is to develop tools for diagnosis and and therapies, especially cancer. This activity addresses several issues:

  1. Synthetic (novel synthetic routes developed by the group, some of this technology has been patented and other is in the process of development.
  2. Manufacturing and functionalization of nanoparticles);
  3. Structural (characterization of nanoparticles using different methods: XRD, TEM, AFM, SAXS, SANS, DLS, ...),
  4. Physical properties (magnetic, optical, ...),
  5. Effectiveness as contrast agents in magnetic resonance imaging in hyperthermic treatment, and
  6. Cellular studies in vitro and in vivo (toxicology, immunology, hematology, cellular internalization, acting on cellular organelles, tissue distribution, ...).

In the current state of development it provides a polymeric nanoplatform which in addition to magnetic functionality can also incorporate luminescent components and anchor groups of biomolecules (proteins in general and specific antibodies). It is composed of biocompatible elements (maghemite and biocompatible polymer), with low toxicity, no hematologic problems , has significant magnetothermic response and acts as an effective contrast agent in MRI . This is a multidisciplinary activity carried out in collaboration with other national groups (Faculty of Veterinary Medicine, Clinical Hospital, Univ Salamanca, Polytechnic University of Madrid, Universidad Complutense, Centro de Investigación Príncipe Felipe) and abroad (University of Aveiro , Univ Pavia, INSA Toulouse, IMEG Sweden, McGill University, Montreal, Canada, CIM Cuba, Technical University of Vienna, University of Lisbon).

 

Magnetic Crystallography with Neutrons and Advanced Neutron Instrumentation

Magnetic Crystallography with Neutrons and Advanced Neutron Instrumentation within the CRG´s framework of the ILL.

This line of research supports work being carried out within the other two research lines of the group when characterization by neutron scattering is required. It also involves the development of advanced instrumentation focused on the improvement and development of existing instruments and the design and construction of new ones. Finally, it also includes a component of National Service by members of the group responsible for coordinating the domestic use of the Spanish Collaborative Research Group (CRG) instruments at the ILL and collaboration with local scientists on selected experiments.

 

Thermometry in the nanoscale

This topic is being developed in closed collaboration with the group of Prof. Luis Carlos, from the University of Aveiro. It is based in the recent discovery by the groups of a molecular system that works as a self-referencing thermometer. The system is very versatile and can be attached to particules, surfaces or processed in a paint. The topic aims to explore the possibilities of this system and its practical applications.

Internacionales

Prof. L. Carlos, CICECO and Aveiro University, Portugal.

Dr. Nuno Silva, CICECO and Aveiro University, Portugal.

Prof. Dante Gatteschi,  Prof. Andrea Caneschi,  European Institute of Molecular Magnetism (EIMM), Florence, Italy. 

Prof. U. Schubert,  Technical University of Wien, Austria.

Prof. Masaaki Ohba, Fukuoka University, Fukuoka, Japan.

Prof. Katsuya Inoue, Hiroshima  University, Hiroshima, Japan.

Prof.  Joel Miller,  Utah University, Salt Lake City, Utah, USA.

Profª. Yuko Hosokoshi, Osaka Prefecture University, Osaka, Japan.

Profª Pasquina  Marzola, Verona University, Verona, Italy.

Dr. Alessandro Lascialfari, Pavia University, Pavia, Italy.

Profª Dusica Maysinger,  McGill University, Montreal, Canada. 

Dr. G. Baldi, Centro Recerche Colorobbia, Sovigliana Vinci, Italy.

Prof. Marc Raspaud and Dr. Julian Carrey, INSA-Toulouse, Toulouse, France.

Prof. Juraj Černák, Department of Inorganic Chemistry, Institute of Chemistry, P. J. Šafárik University in Košice, Košice, Slovakia

Dr. Claudio Sangregorio, University of Florence, Florence, Italy.

Dr. Dino Fiorani, CNR-ICMAT, Rome, Italy.

Prof. Masaki Mito, Kyushu Institute of Technology, Kitakyushu, Japan.

Prof. Rogerio Gaspar, University of Lisbon, Lisboa, Portugal.

Prof. Ruth Duncan, Cardiff University, Cardiff, UK.

Prof. Heinrich Hoffman, EPFL, Lausanne, Swiss.

Prof. Silvio Decurtins, Bern University, Bern, Swiss.

Prof. Jeremy Rawson, Windsor University, Windsor, Canada.

Prof. Paul Lahti, University of Massachusetts, Amherst, Mass., USA.

Dr. Carley Paulsen, CNRS, Grenoble, France.

Dr. Eric Ressouche, CEA-Grenoble, Grenoble, France.

Dr. Jean Pascal Sutter, Toulouse University, Toulouse, France.

Dr. Tatiana Makarova, Umea University, Umea, Sweden.

Dr. Steve Hull, The ISIS Facility, Rutherford Appleton Laboratory, Didcot (UK).

 

Nacionales

Prof. Víctor Sorribas, Cátedra de Toxicología de la Univesidad de Zaragoza, España.

Prof. Eugenio Coronado,  Instituto de Ciencia Molecular, Universidad de Valencia, España.

Dra. Pilar Marco, Instituto de Investigaciones Químicas y Ambientales de Barcelona, España.

Prof. Javier Serrano (Escuela Técnica de Ingenieros de Telecomunicaciones), Zaragoza, España.

Prof. Jaume Veciana Miró Instituto de Ciencias de Materiales de Barcelona, Barcelona, España.

Dr. Manuel Fuentes, Centro Nacional del Cancer de Salamanca (CSIC), Salamanca, España.

Dr. Simó Schwartz, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, España.

Prof. Lluisa Pérez-García, IN2UB, Universitat de Barcelona, Barcelona, España.

Dr. Jose Antonio Plaza, Institute of Microelectronics of Barcelona, IMB-CNM (CSIC), Barcelona, España.

Dr. Jordi Llop, BiomaGUNE, San Sebastian, España.

Prof. Juan Novoa, Universidad de Barcelona, España.

Dr. Enrique Navarro, Instituto Pirenaico de Ecología (CSIC), Zaragoza, España.

Dr. Jesús Martínez de la Fuente, Instituto de Nanociencia de Aragón, Zaragoza, España.

Prof. José Mª Valpuesta, Centro Nacional de Biotecnología (CSIC), Madrid, España.

Prof. Marcelo de las Heras, Universidad de Zaragoza, Zaragoza, España.

Dra. Mª Jesús Vicent, Instituto Príncipe Felipe, Valencia, España.

Profª, Mª Puerto Morales, Instituto de Ciencia de Materiales de Madrid (CSIC), Madrid, España.

Prof. Amilcar Labarta, Universidad de Barcelona, Barcelona, España.

Prof. Fernando Rodríguez, Universidad de Cantabria, Santander, España.

Prof. José González Calbet, Universidad Complutense, Madrid, España.

Dr. Miquel Vellvehi, Instituto de Microelectronica of Barcelona, IMB-CNM (CSIC), Barcelona, España.

Prof. Larry Falvello, University of Zaragoza, Zaragoza, España.

Development of magnetic nanoparticles and ferrofluids for biomedical applications

Highly stable PBS suspensions of colloidal magnetic nanoparticles can be prepared for a variety of applications: MRI contrast agents, hiperthermia, magnetic separation and others. The particles, which can simultaneously incorporate a luminescent element, a mulecular thermometer or a drug, can also be vectorised with a large number of antibodies and proteids.

 

Nanoscale thermometry

Developments for mapping temperature with submicrometric resolution are accepted uppon request. They include application in microelectronics, chips thermometry, intracellular thermometry and nanofluids.